Fast brain waves: A better biomarker for epilepsy

The Vector blog of Boston Children’s Hospital just published a new article entitled “Fast brain waves: A better biomarker for epilepsy” reporting our study on high-frequency oscillations as non-invasive biomarker of epilepsy in children.

Vector is Boston Children’s Hospital’s blog about research and innovation in pediatric and adult medicine. It reports and comments on medical innovations and advances – from bench to bedside – touching on scientific, business and policy issues.

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Job Opening at Children’s Brain Dynamics Laboratory

Job Opening: We invite applications for a Research Assistant position in pediatric neuroimaging. The successful candidate will carry out studies of human brain development by using a combination of different neuroimaging techniques, such as MEG, EEG and DTI. The focus of the studies is two common pediatric neurological disorders, epilepsy and cerebral palsy.

This Research Study Assistant II will be responsible for:

  • Organization of data and research documentation.
  • Experimental setup of pediatric neuroimaging studies.
  • Acquisition/collection of electrophysiological data (i.e. MEG, EEG, MRI, etc) from healthy as well as sick newborn, babies, and children.
  • Analysis and evaluation of electrophysiological data by using sophisticated software analysis tools such as BrainStorm, etc.

To qualify, you must have:

  • A BSc in neuroscience, biomedical engineering, or related field andone year working experience in a similar position.
  • Practical experience in the acquisition of neuroimaging data, a great plus.
  • The ability to communicate well with scientific colleagues and pediatric participants in our experiments.
  • An interest in working with newborns, babies and children, studying brain development either as a career or as a training opportunity.

To apply, go this link or contact Dr. Christos Papadelis (Christos.Papadelis@childrens.harvard.edu) for more information.

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Review Paper Published in Frontiers in Neurology

In January, our team published a review paper in Frontiers in Neurology titled “Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy”. This paper conducts a thorough critical review of the recent MEG literature that investigates high frequency oscillations (HFOs) in patients with epilepsy, summarizing the different methodological approaches and the main findings. You can find a link to the article here.

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Division of Newborn Medicine Holiday Brunch

Our group had an amazing time this past weekend at our Department’s Holiday brunch at the Boston Harbor Hotel. It was great to spend time with family and friends to celebrate the end of the 2016 and the beginning of a productive new year.

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The FNNDSC Group

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Our group braving the cold Boston weather for a quick photo!

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November and December Updates

Christos was selected to be an Academic Editor in PLOS One.

Our team’s video-article “Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography As Biomarker of Pediatric Epilepsy” was selected to be featured in the December edition of JoVE’s monthly newsletter This Month in JoVE, which highlights innovative and unique research being released monthly in the journal.

Christos was invited by Dr. Philip Pearl, Director of the Epilepsy Division, to give a talk for the Epilepsy Grand Rounds at Boston Children’s Hospital on “MEG and EEG Source Localization: basic principles and application in epilepsy“.

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Eleonora was selected to give a talk at the American Epilepsy Society Conference in Houston, Texas (December 2-6, 2016) on “Non-Invasive Localization of High Frequency Oscillations with Simultaneous MEG and Scalp EEG in Children with Epilepsy.” Our team was also selected to present our poster “Noninvasive identification of concurrent high frequency oscillations and spikes in children with epilepsy” at the conference.

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Eleonora presenting her poster at the American Epilepsy Society Conference in Houston, Texas

We hope everyone has a great Thanksgiving and Holiday season, and can’t wait to see what 2017 brings!

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July-October Updates

Christos published a chapter in March entitled “Neuroimaging in neonatal seizures” in the book Neonatal Seizures: Current management and future challenges, Chapter: 6, Publisher: Mac Keith Press, Editor: Lakshmi Nagarajan, pp.76-99.

Christos was selected as Team Leader for happiness in the Human Affectome Project .

Christos was selected to present two abstracts [1] [2] on cerebral palsy at the 22nd Annual Meeting of the Organization for Human Brain Mapping Conference (June 26-30, 2016).

Christos published an article in August in Clinical Neurophysiology entitled, “Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment”. One of our former interns, Fatemeh Ashkezari, was also featured in this article.

In September, Christos was selected to present two talks at the American Academy for Cerebral Palsy and Developmental Medicine Conference in Hollywood, Florida (September 20-24, 2016): “Reorganization of the Somatosensory Cortex in Children with Cerebral Palsy due to Impaired Thalamocortial Sensory Tracts”, and “Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Cerebral Palsy”. He was also selected to serve on the Research Committee for the organization.

Christos was invited by Dr. Charles Berde, Division Chief of Pain Medicine and Professor of Anesthesia, to give a talk to the Department of Anesthesiology, Perioperative, and Pain. He presented on “Advanced Multimodal Neuroimaging for Studying Cerebral Palsy and Epilepsy”.

Christos was invited to give a talk in Seoul, South Korea for the International Conference on Biomagnetism (October 1-6, 2016)  for his work with cerebral palsy entitled “Multimodal neuroimaging in children with cerebral palsy to assess cortical reorganization in relation to upper limb function”.

Christos was invited to give a talk as a keynote speaker at the Society of Applied Neuroscience meeting in Corfu, Greece (October 6-9, 2016). He presented on Advanced Multimodal Neuroimaging for Studying Prevalent Neurological Pediatric Disorders.

Eleonora received the Travel and Professional Development award from the Boston Children’s Hospital Postdoctoral Association and Office of Fellowship Training, and the Early Investigator Travel Award from the committee of the International Workshop on High-Frequency Oscillations in Freiburg, Germany (March 10-12, 2016).

Stay tuned for more updates!

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Welcome New Interns

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R-L: Selin, Charlotte, Enrico, Christos, Eleonora, Stefania, Madelyn

This summer our lab is delighted to welcome our new interns to the group.

Selin Ozcan – Selin is currently analyzing data from children with autism to detect abnormalities in the cerebellum when they are presented with happy, angry, and neutral faces. Selin has been working at BCH since August of 2016. Selin received her Bachelor’s of Science from the Istanbul Bilgi University in physical therapy and rehabilitation. She is currently attending the Uskudar University to receive her Master’s degree in neuroscience.

Charlotte Guarassi – Charlotte is helping with the setup and execution of developing a method to quantify pain levels in children in the NICU. Charlotte has been working at BCH since September of 2016. She received her Bachelor’s of Science in Industrial Engineering from Campus Biomedico of Rome, where she is currently attending to receive her Master’s degree in biomedical engineering.

Enrico Lombardi – Enrico is helping identify red and green spikes in the high frequency oscillations of children with epilepsy. Enrico has been working at BCH since September of 2016. He received his Bachelor’s of Science in industrial engineering from Campus Biomedico of Rome, where he is currently attending to receive her Master’s degree in biomedical engineering.

Stefania Percivati – Stefania is working on analyzing the propagation of high frequency oscillations in children with epilepsy. She has been working at BCH since September 2016. She received her Bachelor’s of Science in biomedical engineering from the Tor Vergata University of Rome. She is currently attending Campus Biomedico of Rome to receive her Master’s Degree in biomedical engineering.

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